Reaction: ABHD10 hydrolyses MPAG
- in pathway: Glucuronidation
Mycophenolic acid (MPA) is the active metabolite of the immunosuppressant drug mycophenolate mofetil (MMF) and is primarily metabolised by glucuronidation to a phenolic glucuronide (MPAG) and an acyl glucuronide (AMPAG), a potential immunotoxic metabolite. Mitochondrial mycophenolic acid acyl-glucuronide esterase (ABHD10) deglucuronidates AMPAG thereby ABHD10 could play a role in the protection against acyl glucuronide-induced toxicity (Iwamura et al. 2012).
Reaction - small molecule participants:
GlcA [mitochondrial matrix]
MPA [mitochondrial matrix]
AMPAG [mitochondrial matrix]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-5694563
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Reaction input - small molecules:
mycophenolic acid O-acyl-glucuronide
water
Reaction output - small molecules:
D-glucuronate
mycophenolate
Reactome.org link: R-HSA-5694563