Reaction: ABHD4 hydrolyses NAPE
- in pathway: Acyl chain remodelling of PE
Abhydrolase domain-containing protein 4 (ABHD4) is a regulator of endocannabinoid signalling and suppressor of tumor growth. Its physiological substrates are both N-acyl phosphatidylethanolamine (NAPE) and a wide range of lysoNAPEs. Shown here, ANHD4 mediates the hydrolysis of NAPE to glycerophospho-arachidonyl ethanolamine (GPAEA), an endocannabanoid (Simon & Cravatt 2006).
Reaction - small molecule participants:
GPAEA [endoplasmic reticulum membrane]
acyl group [endoplasmic reticulum membrane]
NAPE [endoplasmic reticulum membrane]
H2O [cytosol]
Reactome.org reaction link: R-HSA-5694583
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Reaction input - small molecules:
N-acylphosphatidylethanolamine
water
Reaction output - small molecules:
N-arachidonoylphosphatidylethanolamine
acyl group
Reactome.org link: R-HSA-5694583