Reaction: ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA
- in pathway: Synthesis of very long-chain fatty acyl-CoAs
Long-chain fatty acid-CoA ligases 1 and 2 (ACSBG1 and 2) are capable of activating very long-chain fatty acids (VLCFA) and are thought to play a role in fatty acid metabolism in the brain (ACSBG1 and 2) (Steinberg et al. 2000, Pei et al. 2003), and testes (ACSBG2) (Pei et al. 2006).
Reaction - small molecule participants:
PPi [cytosol]
VLCFA-CoA [cytosol]
AMP [cytosol]
ATP [cytosol]
VLCFA [cytosol]
CoA-SH [cytosol]
Reactome.org reaction link: R-HSA-5695957
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Reaction input - small molecules:
ATP(4-)
very long-chain fatty acid
coenzyme A(4-)
Reaction output - small molecules:
diphosphate(3-)
very long-chain fatty acyl-CoA
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-5695957