Reaction: ACAD10 dehydrogenates S-2MPDA-CoA
- in pathway: Mitochondrial Fatty Acid Beta-Oxidation
Acyl-CoA dehydrogenase family member 10 (ACAD10) is a mitochondrial enzyme that can catalyse the alpha, beta-dehydrogenation of acyl-CoA esters. ACAD10 shows highest expression in foetal brain and is shown to be active only on S-2-methylpentadecenoyl-CoA (S-2MPDA-CoA), a C15 acyl-CoA. The S isomer is dehydrogenated to its respective 2,3-dehydroacyl-CoA product, S-2methyl-2,3-dehydropentadecenoyl-CoA (S-2MDPDA) (He et al. 2011).
Reaction - small molecule participants:
S-2MDPDA-CoA [mitochondrial matrix]
FADH2 [mitochondrial matrix]
FAD [mitochondrial matrix]
S-2MPDA-CoA [mitochondrial matrix]
Reactome.org reaction link: R-HSA-5695980
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Reaction input - small molecules:
FAD(3-)
2-methylpentadecenoyl-CoA
Reaction output - small molecules:
2-methylpentadec-2-enoyl-CoA
FADH2(2-)
Reactome.org link: R-HSA-5695980