Reaction: ACSF2 ligates CoA-SH to MCFA
- in pathway: Mitochondrial Fatty Acid Beta-Oxidation
Acyl-coenzyme A synthetases (ACSs) catalyse the activation of fatty acids by thioesterification to CoA, the fundamental initial reaction in fatty acid metabolism. Mitochondrial acyl-CoA synthetase family member 2 (ACSF2) preferentially ligates CoA-SH to medium-chain fatty acids (MCFA), around C8 in length (Watkins et al. 2007).
Reaction - small molecule participants:
AMP [mitochondrial matrix]
PPi [mitochondrial matrix]
MCFA-CoA [mitochondrial matrix]
CoA-SH [mitochondrial matrix]
ATP [mitochondrial matrix]
MCFA [mitochondrial matrix]
Reactome.org reaction link: R-HSA-5696004
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Reaction input - small molecules:
coenzyme A(4-)
ATP(4-)
medium-chain fatty acid
Reaction output - small molecules:
adenosine 5'-monophosphate(2-)
diphosphate(3-)
medium-chain fatty acyl-CoA
Reactome.org link: R-HSA-5696004