Reaction: ACSF3 ligates CoA-SH to VLCFA
- in pathway: Synthesis of very long-chain fatty acyl-CoAs
Acyl-coenzyme A synthetases (ACSs) catalyse the activation of fatty acids by thioesterification to CoA, the fundamental initial reaction in fatty acid metabolism. Mitochondrial acyl-CoA synthetase family member 3 (ACSF3) preferentially ligates CoA-SH to very long-chain fatty acids (VLCFA), around C24 in length (Watkins et al. 2007).
Reaction - small molecule participants:
AMP [mitochondrial matrix]
PPi [mitochondrial matrix]
VLCFA-CoA [mitochondrial matrix]
CoA-SH [mitochondrial matrix]
VLCFA [mitochondrial matrix]
ATP [mitochondrial matrix]
Reactome.org reaction link: R-HSA-5696007
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Reaction input - small molecules:
coenzyme A(4-)
very long-chain fatty acid
ATP(4-)
Reaction output - small molecules:
adenosine 5'-monophosphate(2-)
diphosphate(3-)
very long-chain fatty acyl-CoA
Reactome.org link: R-HSA-5696007