Reaction: ADPGK:Mg2+ phosphorylates Glc to G6P
- in pathway: Glycolysis
Glucose phosphorylation is a central event in cellular metabolism. ADP-dependent glucokinase (ADPGK) can phosphorylate glucose (Glc) using ADP as the phosphate donor to glucose 6-phopshate (G6P). To date, it has not been established whether this phosphorylation supports a significant role in priming glucose for a metabolic fate other than glycolysis (Richter et al. 2012). Stdies of metabolic changes during T cell activation suggest a role for it there (Kaminski et al. 2012).
Reaction - small molecule participants:
G6P [cytosol]
AMP [cytosol]
ADP [cytosol]
Glc [cytosol]
Reactome.org reaction link: R-HSA-5696021
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Reaction input - small molecules:
ADP(3-)
alpha-D-glucose
Reaction output - small molecules:
alpha-D-glucose 6-phosphate(2-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-5696021