Reaction: ALDH8A1 oxidises 9cRAL to 9cRA
- in pathway: RA biosynthesis pathway
Aldehyde dehydrogenase family 8 member A1 (ALDH8A1, ALDH12) can preferentially mediate the oxidation of 9-cis-retinal (9cRAL) into the retinoid X receptor ligand 9-cis-retinoic acid (9cRA) (Lin & Napoli 2000). ALDH8A1 might function in the pathway of 9-cis-retinal metabolism.
Reaction - small molecule participants:
H+ [cytosol]
9cRA [cytosol]
NADH [cytosol]
H2O [cytosol]
9cRAL [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-5696101
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Reaction input - small molecules:
water
9-cis-retinal
NAD(1-)
Reaction output - small molecules:
hydron
9-cis-retinoic acid
NADH(2-)
Reactome.org link: R-HSA-5696101