Reaction: AOC1 deaminates Hist
- in pathway: Phase I - Functionalization of compounds
Amiloride-sensitive, copper-containing amine oxidase (AOC1) can catalyse the oxidative deamination of diamines, particularly histamine (Hist) (McGrath et al. 2009). Histamine is involved in allergic and immune responses.
Reaction - small molecule participants:
H+ [extracellular region]
NH3 [extracellular region]
H2O2 [extracellular region]
I4AH [extracellular region]
H2O [extracellular region]
Hist [extracellular region]
O2 [extracellular region]
Reactome.org reaction link: R-HSA-5696131
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Reaction input - small molecules:
water
histaminium
dioxygen
Reaction output - small molecules:
hydron
ammonia
hydrogen peroxide
imidazole-4-acetaldehyde
Reactome.org link: R-HSA-5696131