Reaction: AOC2 deaminates TYR
- in pathway: Phase I - Functionalization of compounds
Retina-specific copper amine oxidase (AOC2) is present on the cell surface of most cells but especially retinal cells. It is classed as a semicarbazide-sensitive amine oxidase (SSAO) and catalyses the oxidative deamination of aromatic amines such as tyramine (TYR, shown here), 2-phenylethylamine and tryptamine (Kaitaniemi et al. 2009, Bour et al. 2007). Overexpression of AOC2 could result in tissue destruction seen in ocular pathologies.
Reaction - small molecule participants:
H+ [extracellular region]
NH3 [extracellular region]
H2O2 [extracellular region]
4HPAA [extracellular region]
H2O [extracellular region]
TYR [extracellular region]
O2 [extracellular region]
Reactome.org reaction link: R-HSA-5696146
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Reaction input - small molecules:
water
tyramine
dioxygen
Reaction output - small molecules:
hydron
ammonia
hydrogen peroxide
(4-hydroxyphenyl)acetaldehyde
Reactome.org link: R-HSA-5696146