Reaction: AOC3 deaminates BZAM
- in pathway: Phase I - Functionalization of compounds
Membrane primary amine oxidase (AOC3, aka vascular adhesion protein 1, VAP-1) is a membrane-bound, dimeric enzyme that can catalyse the oxidative deamination of primary amines such as benzylamine (BZAM) and methyalmine to their respective aldehydes (Kaitaniemi et al. 2009, Bour et al. 2007). It is widely expressed with highest expression in peripheral lymph nodes, hepatic endothelia, appendix, lung and small intestine (Smith et al. 1998).
Reaction - small molecule participants:
H+ [extracellular region]
BZAL [extracellular region]
NH3 [extracellular region]
H2O2 [extracellular region]
H2O [extracellular region]
O2 [extracellular region]
BZAM [extracellular region]
Reactome.org reaction link: R-HSA-5696183
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Reaction input - small molecules:
water
dioxygen
benzylaminium
Reaction output - small molecules:
hydron
benzaldehyde
ammonia
hydrogen peroxide
Reactome.org link: R-HSA-5696183