Reaction: PXLP-K278-PHYKPL tetramer hydrolyses 5PHL
- in pathway: Lysine catabolism
In mitochondria, ethanolamine-phosphate phospho-lyase and 5-phosphohydroxy-L-lysine phospho-lyase (ETNPPL and PHYKPL respectively) are two closely related pyridoxal-phosphate-dependent, homotetrameric ammoniophospholyases that hydrolyse phosphoethanolamine (PETA) and 5-phosphohydroxylysine (5PHL) respectively (Veiga-da-Cunha et al. 2012). PETA is a component and a precursor of phospholipids whereas 5PHL is a breakdown product of collagen. ETNPPL utilises one pyridoxal 5'-phosphate (PXLP) as cofactor per subunit.
Reaction - small molecule participants:
Pi [mitochondrial matrix]
NH3 [mitochondrial matrix]
2AMAS [mitochondrial matrix]
5PHL [mitochondrial matrix]
H2O [mitochondrial matrix]
Pi [mitochondrial matrix]
NH3 [mitochondrial matrix]
2AMAS [mitochondrial matrix]
5PHL [mitochondrial matrix]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-5696408
======
Reaction input - small molecules:
erythro-5-phosphonooxy-L-lysine
water
erythro-5-phosphonooxy-L-lysine
water
Reaction output - small molecules:
hydrogenphosphate
ammonia
L-allysine zwitterion
hydrogenphosphate
ammonia
L-allysine zwitterion
Reactome.org link: R-HSA-5696408