Reaction: PXLP-K278-ETNPPL tetramer hydrolyses PETA
- in pathway: Synthesis of PE
In mitochondria, ethanolamine-phosphate phospho-lyase and 5-phosphohydroxy-L-lysine phospho-lyase (ETNPPL and PHYKPL respectively) are two closely related pyridoxal-phosphate-dependent, homotetrameric ammoniophospholyases that hydrolyse phosphoethanolamine (PETA) and 5-phosphohydroxylysine (5PHL) respectively (Veiga-da-Cunha et al. 2012). PETA is a component and a precursor of phospholipids whereas 5PHL is a breakdown product of collagen. ETNPPL utilises one pyridoxal 5'-phosphate (PXLP) as cofactor per subunit.
Reaction - small molecule participants:
Pi [mitochondrial matrix]
CH3CHO [mitochondrial matrix]
NH3 [mitochondrial matrix]
PETA [mitochondrial matrix]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-5696415
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Reaction input - small molecules:
O-phosphoethanolamine
water
Reaction output - small molecules:
hydrogenphosphate
acetaldehyde
ammonia
Reactome.org link: R-HSA-5696415