Reaction: AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters
- in pathway: Arachidonic acid metabolism
Arachidyl alcohol (ARACOH) is straight-chain fatty alcohol of C20 length used as an emollient in cosmetics. Esterification of alcohols with fatty acids represents the formation of both storage and cytoprotective molecules in the body. Overproduction of these esters is associated with several disease pathologies, including atherosclerosis and obesity. The ER membrane-associated acyl-CoA wax alcohol acyltransferase 1 (AWAT1) mediates the esterification of its preferred substrate ARACOH (Turkish et al. 2005).
Reaction - small molecule participants:
arachidyl ester [endoplasmic reticulum lumen]
CoA-SH [endoplasmic reticulum lumen]
Acyl-CoA [endoplasmic reticulum lumen]
ARACOH [endoplasmic reticulum lumen]
arachidyl ester [endoplasmic reticulum lumen]
CoA-SH [endoplasmic reticulum lumen]
Acyl-CoA [endoplasmic reticulum lumen]
ARACOH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-5696424
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Reaction input - small molecules:
acyl-CoA
icosan-1-ol
acyl-CoA
icosan-1-ol
Reaction output - small molecules:
wax ester
coenzyme A(4-)
wax ester
coenzyme A(4-)
Reactome.org link: R-HSA-5696424