Reaction: AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG
- in pathway: Acyl chain remodeling of DAG and TAG
Acyl-CoA wax alcohol acyltransferase 2 (AWAT2 aka MFAT) is an enzyme highly expressed in skin and thought to play an important role in lipid metabolism in skin. AWAT2 can transfer an acyl group from acyl-CoA to monoacylglycerol, long-chain alcohol, and retinol to form diacylglycerols, wax monoesters and retinyl esters, respectively. Human skin surface lipids are mainly composed of triacylglycerol and wax monoesters (Yen et al. 2005, Turkish et al. 2005).
Reaction - small molecule participants:
CoA-SH [cytosol]
DAG [endoplasmic reticulum membrane]
MAG [endoplasmic reticulum membrane]
Acyl-CoA [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-5696448
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Reaction input - small molecules:
monoacylglycerol
acyl-CoA
Reaction output - small molecules:
coenzyme A(4-)
1,2-diacyl-sn-glycerol
Reactome.org link: R-HSA-5696448