Reaction: USP45 deubiquitinates ERCC1
- in pathway: Formation of Incision Complex in GG-NER
USP45 ubiquitin protease, mutated in prostate cancer and B-cell lymphoma, deubiquitinates ERCC1. While the mechanism and timing of ERCC1 ubiquitination are not known, deubiquitination of ERCC1 by USP45 enables ERCC1 recruitment to DNA damage sites in nucleotide excision repair (NER) and repair of interstrand cross-links (ICLR) (Perez-Oliva et al. 2015).
Reaction - small molecule participants:
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-5696465
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-5696465