Reaction: USP18 deubiquitinates TAK1:TAB1
- in pathway: Ub-specific processing proteases
Ubiquitination plays a key role in the regulation of signaling via TAK1 (Chen 2012). USP18 catalyzes the deubiquitination of the TAK1:TAB1 complex, reversing TAK1 activating ubiquitination, which restricts activation of NF-kappaB, NFAT and JNK and in decreases the expression of IL2 in T cells after TCR activation (Liu et al. 2013).
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-5696534
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-5696534