Reaction: USP25 deubiquitinates DDX58
- in pathway: Ub-specific processing proteases
USP25, a negative regulator of the virus-triggered type I IFN signaling pathway, cleaves lysine 48- and lysine 63-linked polyubiquitin chains in vitro and in vivo from DDX58 (Retinoic acid-inducible gene I (RIG-I)), Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and TRAF6 to inhibit RIG-I-like receptor-mediated IFN signaling (Zhong et al. 2013).
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-5696564
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-5696564