Reaction: USP12, USP26 deubiquitinate AR
- in pathway: Ub-specific processing proteases
USP12 (as part of a complex with WDR48 and WDR20) and USP26 can bind the androgen receptor and promote its deubiquitination (Faus et al. 2005, Burska et al. 2013, Dirac & Bernards 2010). USP26 is specifically expressed in testis tissue and is a potential infertility gene (Stouffs et al. 2005).
Reaction - small molecule participants:
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-5696605
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-5696605