Reaction: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
- in pathway: Ub-specific processing proteases
CYLD removes Lys63-linked ubiquitin chains, acting as a negative regulator of NF-kappa-B signaling (Trompouki et al. 2003). It deubiquitinates several NF-kappa-B regulators including TRAF2, TRAF6 (Kovalenko et al. 2003, Trompouki et al. 2003), IKBKG (NEMO) (Brummelkamp et al. 2003), and RIPK1 (Wright et al. 2007).
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-5696627
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-5696627