Reaction: PARP1 or PARP2 PARylates DDB2 and autoPARylates
- in pathway: DNA Damage Recognition in GG-NER
PARP1 and/or PARP2 homo- or heterodimers recruited to global genomic nucleotide excision repair (GG-NER) site poly(ADP)ribosylate (PARylate) DDB2 and also progressively autoPARylate. PARylation promotes retention of DDB2 at DNA damage sites (Pines et al. 2012, Robu et al. 2013).
Reaction - small molecule participants:
NAM [nucleoplasm]
NAD+ [nucleoplasm]
Reactome.org reaction link: R-HSA-5696655
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Reaction input - small molecules:
NAD(1-)
Reaction output - small molecules:
nicotinamide
Reactome.org link: R-HSA-5696655