Reaction: USP28 deubiquitinates CLSPN and MYC
- in pathway: Ub-specific processing proteases
USP28 is Involved in DNA damage induced apoptosis by specifically stabilizing and deubiquitinating proteins of the DNA damage pathway including CLSPN (Zhang et al. 2006). It also binds to the nucleoplasmic alpha isoform of Fbw7, counteracting FBW7 ubiquitin ligase activity by deubiquitinating MYC in the nucleoplasm, which reduces MYC proteasomal degradation (Popov et al. 2007).
Reaction - small molecule participants:
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-5696914
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-5696914