Reaction: USP44 deubiquitinates CDC20
- in pathway: Ub-specific processing proteases
USP44 specifically mediates the deubiquitination of CDC20, which promotes the association of MAD2L1 and CDC20, which in turn increases the stabilty of the MAD2L1-CDC20-APC/C ternary complex (Mitotic Checkpoint Complex), thereby preventing premature activation of the Anaphase Promoting Complex/Cyclosome (APC/C) (Stegmeier et al. 2007).
Reaction - small molecule participants:
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-5696958
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-5696958