Reaction: USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2
- in pathway: Ub-specific processing proteases
USP37 deubiquitinates Lys-11-linked polyubiquitin chains from cyclin-A (CCNA1 and CCNA2), which opposes the Lys-11-linked polyubiquitination mediated by the anaphase-promoting complex (APC/C) during G1/S transition, thereby promoting S phase entry. Phosphorylation by CDK2 at Ser-628 during G1/S phase maximizes USP37 deubiquitinase activity (Huang et al. 2011).
Reaction - small molecule participants:
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-5697009
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-5697009