Reaction: SLC22A18 exchanges extracellular organic cations for cytosolic H+
- in pathway: Organic cation transport
The human gene SLC22A18 encodes organic cation transporter-like protein 2 (ORCTL2). It is expressed at high levels in kidney, liver and colon and at lower levels in heart, brain and lung. ORCTL2 can transport chloroquine and quinidine with the antiport of protons (Reece et al. 1998). Defects in SLC22A18 may play a role in tumorigenesis (Schwienbacher et al. 1998). How SLC22A18 might be involved in growth regulation is poorly understood. There is speculation that it may be involved in resistance to chemotherapy drugs and/or in the export of genotoxic substances whose retention may increase the risk of tumor formation.
Reaction - small molecule participants:
H+ [extracellular region]
H+ [cytosol]
Reactome.org reaction link: R-HSA-597628
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Reaction input - small molecules:
hydron
Reaction output - small molecules:
hydron
Reactome.org link: R-HSA-597628