Reaction: Activation of highly calcium permeable nicotinic acetylcholine receptors
Nicotinic acetylcholine receptors are activated upon ligand binding which opens the acetylcholine channels and permits Ca2+ and Na+ ion influx depending on the subunit composition and stoichiometry of the subunits. The ratio of Ca2+ to Na+ ion influx varies making the receptors either highly Na+ permeable or Ca2+ permeable.
Reaction - small molecule participants:
Ca2+ [cytosol]
Ca2+ [extracellular region]
Reactome.org reaction link: R-HSA-622326
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Reaction input - small molecules:
calcium(2+)
Reaction output - small molecules:
calcium(2+)
Reactome.org link: R-HSA-622326