Reaction: USP13 deubiquitinates BECN1,USP10
- in pathway: Ub-specific processing proteases
USP13 preferentially cleaves Lys-63-linked polyubiquitin chains (Zhang et al. 2011). It mediates deubiquitination of BECN1, a key regulator of autophagy, which stabilizes PIK3C3/VPS34-containing complexes. USP13 can deubiquitinate USP10, an essential regulator of TP53 stability (Liu et al. 2011).
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-6781779
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-6781779