Reaction: USP19 deubiquitinates RNF123
- in pathway: Ub-specific processing proteases
USP19 is a deubiquitinating enzyme with a preference towards Lys-63-linked ubiquitin chains (Iphofer et al. 2012). It deubiquitinates RNF123, preventing its proteasomal degradation which in turn stimulates CDKN1B ubiquitin-dependent degradation and thereby cell proliferation (Lu et al. 2009).
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-6781814
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-6781814