Reaction: UVSSA:USP7 deubiquitinates ERCC6
- in pathway: Formation of TC-NER Pre-Incision Complex
UVSSA stabilizes ERCC6 (CSB) during transcription-coupled nucleotide excision repair (TC-NER) by targeting ubiquitin protease USP7 to ubiquitinated ERCC6, thus preventing proteasome-mediated degradation of ERCC6. Mutations in UVSSA cause UV-sensitive syndrome (Nakazawa et al. 2012, Schwertman et al. 2012, Zhang et al. 2012, Fei and Chen 2012).
Reaction - small molecule participants:
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-6782069
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-6782069