Reaction: ADAT2:ADAT3 (hetADAT) deaminates adenosine-34 in tRNAs
- in pathway: tRNA modification in the nucleus and cytosol
The ADAT2:ADAT3 heterodimer (hetADAT) deaminates adenosine-34 in 8 human tRNAs: tRNA(Ala-AGC), tRNA(Arg-ACG), tRNA(Ile-AAT), tRNA(leu-AAG), tRNA(Pro-AGG), tRNA(Ser-AGA), tRNA(Thr-AGT), tRNA(Val-AAC) (Torres et al. 2015). The deamination occurs in the nucleus on precursor tRNAs from which the 5' leaders and 3' trailers have not yet been cleaved. The corresponding homologues in Saccharomyces cerevisiae are Tad2p and Tad3p.
Reaction - small molecule participants:
NH3 [nucleoplasm]
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-6782311
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Reaction input - small molecules:
water
Reaction output - small molecules:
ammonia
Reactome.org link: R-HSA-6782311