Reaction: ADAT1 deaminates adenosine-37 in tRNA(Ala)
- in pathway: tRNA modification in the nucleus and cytosol
ADAT1 deaminates adenosine-37 of tRNA(Ala) yielding inosine-37, which may then be methylated to N1-methylinosine-37 (Maas et al. 1999). The homologue in Saccharomyces, Tad1p, catalyzes the same reaction, indicating the deamination of adenosine-37 is highly conserved in eukaryotes.
Reaction - small molecule participants:
NH3 [nucleoplasm]
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-6782336
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Reaction input - small molecules:
water
Reaction output - small molecules:
ammonia
Reactome.org link: R-HSA-6782336