Reaction: EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5
- in pathway: ER Quality Control Compartment (ERQC)
Proteins with major folding defects are extracted from futile folding cycles in the calnexin chaperone system and the ER Quality Control Compartment, and are translocated back to the cytosol for degradation. The ER degradation-enhancing alpha-mannosidase-like proteins 1 and 3 (EDEM1 and 3) can catalyse the sequential hydrolysis of (GlcNAc)2 (Man)8 to (GlcNAc)2 (Man)7-5. The products are recognised by quality control proteins and become targets for ER-associated degradation (ERAD) (Ninagawa et al. 2014, Hirao et al. 2006).
Reaction - small molecule participants:
Man [endoplasmic reticulum quality control compartment]
H2O [endoplasmic reticulum quality control compartment]
Reactome.org reaction link: R-HSA-6782685
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Reaction input - small molecules:
water
Reaction output - small molecules:
D-mannopyranose
Reactome.org link: R-HSA-6782685