Reaction: tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol
- in pathway: tRNA processing in the nucleus
The nuclear export receptor XPOT (Exportin-t) interacts with both tRNA (Li and Sprinzl 2006) and RAN:GTP and the complex is translocated from the nucleus to the cytosol through the nuclear pore (Arts et al. 1998, Kutay et al. 1998, Kuersten et al. 2002, reviewed in Leisegang et al. 2012). RAN:GTP-dependent interactions of XPOT with components of the nuclear pore may increase the efficiency of the transport cycle (Kuersten et al. 2002).
Reaction - small molecule participants:
Pi [cytosol]
Reactome.org reaction link: R-HSA-6783483
======
Reaction input - small molecules:
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-6783483