Reaction: PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro
- in pathway: Glutamate and glutamine metabolism
Pyrroline-5-carboxylate reductase 2 (PYCR2) catalyzes the reaction of (S)-1-pyrroline-5-carboxylate with NADH + H+ to form proline and NAD+ (De Ingeniis et al. 2012). The active enzyme is inferred to be a homodecamer by virtue of its similarity to PYCR1 (Meng et al. 2006). Subcellular fractionation (De Ingeniis et al. 2012) and co-localization studies (Nakayama et al. 2015) indicate that PYCR1 is mitochondrial. Its deficiency is associated with microcephaly and hypomyelination (Nakayama et al. 2015).
Reaction - small molecule participants:
NAD+ [mitochondrial matrix]
L-Pro [mitochondrial matrix]
H+ [mitochondrial matrix]
1PYR-5COOH [mitochondrial matrix]
NADH [mitochondrial matrix]
Reactome.org reaction link: R-HSA-6783939
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Reaction input - small molecules:
hydron
(S)-1-pyrroline-5-carboxylate
NADH(2-)
Reaction output - small molecules:
NAD(1-)
L-proline zwitterion
Reactome.org link: R-HSA-6783939