Reaction: PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)
- in pathway: Glyoxylate metabolism and glycine degradation
GOT2 dimer transaminates 4-OH-L-glutamate (4-OH-L-Glu) and oxaloacetate (OA) to form 4-hydroxy-2-oxoglutarate (HOG) and L-Asp. The ability of human GOT2 to catalyze this reaction has been inferred from studies of its rat homologue (Maitra & Dekker 1964).
Reaction - small molecule participants:
HOG [mitochondrial matrix]
L-Asp [mitochondrial matrix]
4-OH-L-Glu [mitochondrial matrix]
OA [mitochondrial matrix]
Reactome.org reaction link: R-HSA-6784393
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Reaction input - small molecules:
4-hydroxy-L-glutamate(1-)
oxaloacetate(2-)
Reaction output - small molecules:
4-hydroxy-2-oxoglutarate(2-)
L-aspartate(1-)
Reactome.org link: R-HSA-6784393