Reaction: HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate
- in pathway: Glyoxylate metabolism and glycine degradation
Mitochondrial HOGA1 aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate. The biochemical details of the enzyme are inferred from the properties of its well-studied rat homologue (Maitra & Dekker 1964). The mature protein lacks a 25-residue mitochondrial targeting sequence and forms a homotetramer (Riedel et al. 2011).
Reaction - small molecule participants:
glyoxylate [mitochondrial matrix]
PYR [mitochondrial matrix]
HOG [mitochondrial matrix]
Reactome.org reaction link: R-HSA-6784423
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Reaction input - small molecules:
4-hydroxy-2-oxoglutarate(2-)
Reaction output - small molecules:
glyoxylic acid
pyruvate
Reactome.org link: R-HSA-6784423