Reaction: TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs
- in pathway: tRNA modification in the nucleus and cytosol
TRIT1 transfers a dimethylallyl group (isopentenyl group) from dimethylallyl diphosphate to the N6 position of adenosine-37 in tRNA(Ser), yielding N6-dimethylallyladenosine-37 (N6-isopentenyladenosine-37) (Golovko et al. 2000, Spinola et al. 2005, Lamichhane et al. 2013, Yarham et al. 2014, Smaldino et al. 2015). TRIT1 modifies both cytosolic and mitochondrial tRNAs and a mutation in TRIT1 causes mitochondrial respiratory defects (Yarham et al. 2014). Expression of TRIT1 is down-regulated in lung adenocarcinomas compared with normal tissue (Spinola et al. 2005). The homologue in Saccharomyces cerevisiae, MOD5, catalyzes the same reaction.
Reaction - small molecule participants:
PPi [cytosol]
DMAPP [cytosol]
Reactome.org reaction link: R-HSA-6784462
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Reaction input - small molecules:
prenyl diphosphate
Reaction output - small molecules:
diphosphate(3-)
Reactome.org link: R-HSA-6784462