Reaction: HSPG binds LPL dimer
- in pathway: Assembly of active LPL and LIPC lipase complexes
LPL enzyme is catalytically active as a dimer composed of two glycosylated subunits of LPL connected in a head-to-tail arrangement by non-covalent interactions. It is synthesised in adipocytes and exported to the luminal side of the capillary endothelium where it binds heparan sulfate proteoglycan (HSPG), serving as an membrane anchor for the LPL dimer (Lookene et al. 1997, Berryman & Bensadoun 1995).
Reaction - small molecule participants:
HSPG [plasma membrane]
Reactome.org reaction link: R-HSA-6784861
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Reaction input - small molecules:
heparan sulfate proteoglycan
Reaction output - small molecules:
Reactome.org link: R-HSA-6784861