Reaction: CHAC1,2 cleaves GSH to OPRO and CysGly
- in pathway: Glutathione synthesis and recycling
Glutathione-specific gamma-glutamylcyclotransferases 1 and 2 (CHAC1 and 2) catalyse the specific cleavage of glutathione (GSH) into 5-oxoproline (OPRO) and a cysteinylglycine (CysGly) dipeptide. GSH acts a redox buffer in cells and its depletion is an important factor for apoptosis, oxidative stress and progression of cancer. CHAC1 and 2 act as proapototic agents with implications for human health and disease (Mungrue et al. 2009, Crawford et al. 2015).
Reaction - small molecule participants:
OPRO [cytosol]
CysGly [cytosol]
GSH [cytosol]
Reactome.org reaction link: R-HSA-6785928
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Reaction input - small molecules:
glutathionate(1-)
Reaction output - small molecules:
5-oxo-L-prolinate
L-cysteinylglycine zwitterion
Reactome.org link: R-HSA-6785928