Reaction: UGT8 transfers Gal from UDP-Gal to CERA
- in pathway: Glycosphingolipid biosynthesis
2-hydroxyacylsphingosine 1-beta-galactosyltransferase (UGT8) catalyses the transfer of galactosyl moiety from UDP-galactose (UDP-Gal) to ceramide (CERA), a key step in the biosynthesis of galactocerebrosides (GalCer), which are abundant sphingolipids of the myelin membrane of the CNS and PNS (Kapitonov & Yu 1997, Liu et al. 2013).
Reaction - small molecule participants:
GalCer [plasma membrane]
UDP [cytosol]
UDP-Gal [cytosol]
CERA [plasma membrane]
Reactome.org reaction link: R-HSA-6785933
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Reaction input - small molecules:
UDP-alpha-D-galactose(2-)
N-acylsphingoid
Reaction output - small molecules:
N-acyl-beta-D-galactosylsphingosine
UDP(3-)
Reactome.org link: R-HSA-6785933