Reaction: CHST4 transfers SO4(2-) from PAPS to Core 2 mucins
- in pathway: O-linked glycosylation of mucins
Carbohydrate sulfotransferase 4 (CHST4) transfers sulfate (SO4(2-)) from the high energy donor 3'-phospho-5'-adenylyl sulfate (PAPS) to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of mucin-associated glycans that ultimately serve as SELL ligands which are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. CHST4 preferentially sulfates Core 2 mucins (Bistrup et al. 1999). CHST4 is localised to the Golgi membrane (de Graffenried & Bertozzi 2004).
Reaction - small molecule participants:
PAP [Golgi lumen]
PAPS [Golgi lumen]
Reactome.org reaction link: R-HSA-6786012
======
Reaction input - small molecules:
3'-phosphonato-5'-adenylyl sulfate(4-)
Reaction output - small molecules:
adenosine 3',5'-bismonophosphate(4-)
Reactome.org link: R-HSA-6786012