Reaction: CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1
Carbohydrate sulfotransferase 10 (CHST10) transfers sulfate (SO4(2-)) from the high energy donor 3'-phospho-5'-adenylyl sulfate (PAPS) to position 3 of non-reducing glucuronyl (GlcA) residues of N-glycosylated proteins terminating with the saccharide sequence glucuronyl-lactosaminyl (GlcA-LacN), forming the HNK1 carbohydrate (sulfo-3GlcA-beta1,3Gal-beta1,4-GlcNAc-R). The HNK1 carbohydrate is expressed on various adhesion molecules (neural cells, natural killer cells) in the nervous system and may play a role in cell-cell and cell-substratum interactions (Ong et al. 1998, 1999).
Reaction - small molecule participants:
PAP [Golgi lumen]
S-HNK1 carbohydrate [Golgi lumen]
PAPS [Golgi lumen]
HNK1 carbohydrate [Golgi lumen]
Reactome.org reaction link: R-HSA-6786048
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Reaction input - small molecules:
3'-phosphonato-5'-adenylyl sulfate(4-)
beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl group
Reaction output - small molecules:
adenosine 3',5'-bismonophosphate(4-)
3-O-sulfo-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl group
Reactome.org link: R-HSA-6786048