Reaction: Translesion synthesis across unhooked ICL by POLN
- in pathway: Fanconi Anemia Pathway
The error-prone DNA polymerase nu (POLN) performs translesion DNA synthesis using the DNA strand with unhooked interstrand crosslink (ICL) as a template, thereby bypassing the unhooked ICL (Moldovan et al. 2010, Yamanaka et al. 2010). The DNA strand with unhooked ICL is subsequently repaired via nucleotide excision repair (NER), while the double strand break (DSB) generated by incision of the stalled replication fork during the unhooking step is repaired via homologous recombination repair (HRR) (reviewed by Kottemann and Smogorzewska 2013, Deans and West 2011).
Reaction - small molecule participants:
PPi [nucleoplasm]
dNTP [nucleoplasm]
Reactome.org reaction link: R-HSA-6786166
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Reaction input - small molecules:
2'-deoxyribonucleoside triphosphate
Reaction output - small molecules:
diphosphate(3-)
Reactome.org link: R-HSA-6786166