Reaction: CMBL hydrolyses OM to OLMS
- in pathway: Phase I - Functionalization of compounds
Carboxymethylenebutenolidase homolog (CMBL) is a cytosolic hydrolase enzyme present in liver and intestine. It is able to hydrolyse medoxomil-type pro-drugs to their pharmacologically active metabolites. Olmesartan medoxomil (OM) is an angiotensin II type 1 receptor antagonist widely prescribed as an antihypertensive agent. It is hydrolysed by CMBL to its active metabolite olmesartan (OLMS) (Ishizuka et al 2010). True physiological substrates of CMBL remain unknown.
Reaction - small molecule participants:
diketone [cytosol]
H2O [cytosol]
OM [cytosol]
Reactome.org reaction link: R-HSA-6786190
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Reaction input - small molecules:
water
Olmesartan medoxomil
Reaction output - small molecules:
diketone
Reactome.org link: R-HSA-6786190