Reaction: CARNS1 transforms ATP, L-His, b-Ala to CARN
- in pathway: Histidine catabolism
Carnosine (beta-alanyl-L-histidine) and homocarnosine (gamma-aminobutyryl-L-histidine) are abundant dipeptides in skeletal muscle and brain of most vertebrates. Carnosine synthase 1 (CARNS1) transforms ATP, L-histidine (L-His) and beta-alanine (b-Ala) to carnosine (CARN) with much greater efficiency than synthesis of homocarnosine (Drozak et al. 2010).
Reaction - small molecule participants:
CARN [cytosol]
Pi [cytosol]
ADP [cytosol]
L-His [cytosol]
ATP [cytosol]
b-Ala [cytosol]
Reactome.org reaction link: R-HSA-6786245
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Reaction input - small molecules:
L-histidinium(1+)
ATP(4-)
beta-alanine zwitterion
Reaction output - small molecules:
carnosine zwitterion
hydrogenphosphate
ADP(3-)
Reactome.org link: R-HSA-6786245