Reaction: DECR2 reduces LCtE-CoA to t3enoyl-CoA
- in pathway: Beta-oxidation of very long chain fatty acids
Saturated and unsaturated fats can undergo beta-oxidation in the mitochondrion and peroxisomes. The only major difference known so far is that peroxisomes can process linear as well as branched unsaturated fatty acid enoyl-CoA esters with much longer chains (>C20) when compared with the mitochondrion. Peroxisomal 2,4-dienoyl-CoA reductase (DECR2) mediates the reduction of long-chain enoyl-CoA esters (LCtE-CoA) to form trans-3-enoyl-CoA esters (t3enoyl-CoA) (De Nys et al. 2001, Hua et al. 2012). DECR2 functions as an auxiliary enzyme for fatty acid beta-oxidation where very long-chain and long-chain fatty acids are shortened in peroxisomes and shuttled to the mitochondrion for complete degradation.
Reaction - small molecule participants:
t3enoyl-CoA [peroxisomal matrix]
NADP+ [peroxisomal matrix]
H+ [peroxisomal matrix]
LCtE-CoA [peroxisomal matrix]
NADPH [peroxisomal matrix]
Reactome.org reaction link: R-HSA-6786720
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Reaction input - small molecules:
hydron
long-chain 2,3-trans-enoyl CoA(4-)
NADPH
Reaction output - small molecules:
trans-3-enoyl-CoA
NADP(+)
Reactome.org link: R-HSA-6786720