Reaction: TRNT1 polymerizes CCA at the 3' end of pre-tRNA
- in pathway: tRNA processing in the mitochondrion
TRNT1 (CCA-adding enzyme) polymerizes a nontemplated CCA sequence on the 3' end of mitochondrial tRNA (Nagaike et al. 2001). Mutations in TRNT1 or tRNAs that affect the rate of CCA addition cause pathological consequences in humans (Tomari et al. 2003, Chakraborty et al. 2014, Sasarman et al. 2015).
Reaction - small molecule participants:
PPi [mitochondrial matrix]
ATP [mitochondrial matrix]
CTP [mitochondrial matrix]
Reactome.org reaction link: R-HSA-6786881
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Reaction input - small molecules:
ATP(4-)
CTP(4-)
Reaction output - small molecules:
diphosphate(3-)
Reactome.org link: R-HSA-6786881