Reaction: DERA cleaves dR5P to GA3P and CH3CHO
- in pathway: Pentose phosphate pathway
The nucleoside breakdown products ribose-1-phosphate (R1P) and deoxyribose-1-phosphate (dR1P) can be used to produce energy during oxidative or mitochondrial stress to minimize or delay stress-induced damage. Two steps connect these nucleoside breakdown products to central carbon metabolism in mammals. In the second step, deoxy-ribose5-phosphate (dR5P) is cleaved to glyceraldehyde-3-phosphate (GA3P, an intermediate in glycolysis) and acetaldehyde (CH3CHO) by deoxyribose-phosphate aldolase (DERA) (Salleron et al. 2014).
Reaction - small molecule participants:
GA3P [cytosol]
CH3CHO [cytosol]
dR5P [cytosol]
Reactome.org reaction link: R-HSA-6787321
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Reaction input - small molecules:
2-deoxy-D-ribose 5-phosphate(2-)
Reaction output - small molecules:
D-glyceraldehyde 3-phosphate(2-)
acetaldehyde
Reactome.org link: R-HSA-6787321