Reaction: TRIT1 transfers dimethylallyl group to adenosine-37 of tRNA(Ser)
- in pathway: tRNA modification in the mitochondrion
TRIT1 transfers a dimethylallyl group (isopentenyl group) from dimethylallyl diphosphate to the N6 position of adenosine-37 in mitochondrial tRNA(Ser,UCN), yielding N6-dimethylallyladenosine-37 (N6-isopentenyladenosine-37) (Lamichhane et al. 2013, Yarham et al. 2014). TRIT1 modifies both cytosolic and mitochondrial tRNAs and a mutation in TRIT1 causes defects in mitochondrial protein synthesis and respiration (Yarham et al. 2014).
Reaction - small molecule participants:
PPi [mitochondrial matrix]
dimethylallyl-PP [mitochondrial matrix]
Reactome.org reaction link: R-HSA-6787567
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Reaction input - small molecules:
prenyl diphosphate
Reaction output - small molecules:
diphosphate(3-)
Reactome.org link: R-HSA-6787567