Reaction: GMDS dehydrates GDP-Man to GDP-DHDMan
- in pathway: GDP-fucose biosynthesis
The de novo synthesis pathway for GDP-L-fucose is a two step pathway starting from GDP-mannose. In the first step, GDP-mannose (GDP-Man) is dehydrated to GDP-4-dehydro-6-deoxy-alpha-D-mannose (GDP-DHDMan) by GDP-mannose 4,6 dehydratase (GMDS) (Sullivan et al. 1998, Ohyama et al. 1998). Fucosylation is one of the most important oligosaccharide modifications in cancer and inflammation. Defects in GMDS are involved in the progression of colorectal cancer (Nakayama et al. 2013).
Reaction - small molecule participants:
H2O [cytosol]
GDP-DHDMan [cytosol]
GDP-Man [cytosol]
Reactome.org reaction link: R-HSA-6787632
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Reaction input - small molecules:
GDP-alpha-D-mannose(2-)
Reaction output - small molecules:
water
GDP-4-dehydro-6-deoxy-alpha-D-mannose
Reactome.org link: R-HSA-6787632